DC1 PROJECT:
Synthesis of fucose and sialic acid mimetics able to selectively disrupt the function of key glycosyltransferases implicated in cancer. (link)
DC2 PROJECT:
Synthetic approaches for targeting cancer glycosylation. (link)
DC3 PROJECT:
Evaluation of glycosyltransferases inhibitors and targeted approaches in cancer cells and tumour spheroids. (link)
DC4 PROJECT:
Protein expression and purification of FTs and crystallization of FTs and STs complexed to inhibitors. (link)
DC5 PROJECT:
Combotope-specific single chain fragments (scFv) antibodies by Phage Display Technologies. (link)
DC6 PROJECT:
Assay development and activity screening of inhibitors of sialyl and fucosyltransferases. (link)
DC7 PROJECT:
Screening and hit development towards novel non-carbohydrate inhibitors of glycosyl transferase. (link)
DC8 PROJECT:
Structural and dynamics characterization of the complexes of bioactive molecules with GTs and scFv antibodies by NMR. (link)
DC9 PROJECT:
Expression, purification and characterization of sialyltransferases, and validation of glycosyltransferases inhibitors using microplate assays. (link)
DC10 PROJECT:
Testing and validation of inhibitors by engineered cell-based glycan arrays (link)